In the two-group classification, AML samples are basically clustered together no matter rows are scaled are not. Samples can also be separated into three groups where ALL samples are separated into two subgroups.
In the three-group classification, when rows are scaled, only ATC:skmeans generates stable partition (1-PAC score = 0.96), while when rows are not scaled, no method generates stable partitions, as shown in Table 1 and Figure 1.
| Rows are scaled | Rows are unscaled | |
|---|---|---|
| ATC:skmeans | 0.96 | 0.78 |
| SD:skmeans | 0.74 | 0.81 |
| MAD:skmeans | 0.87 | 0.78 |
| CV:skmeans | 0.84 | 0.78 |
| ATC:kmeans | 0.55 | 0.77 |
| SD:mclust | 0.52 | 0.73 |
| CV:mclust | 0.64 | 0.72 |
| SD:kmeans | 0.69 | 0.71 |
| MAD:mclust | 0.56 | 0.7 |
| CV:kmeans | 0.74 | 0.68 |
| ATC:pam | 0.53 | 0.65 |
| MAD:kmeans | 0.72 | 0.64 |
| MAD:pam | 0.45 | 0.56 |
| CV:pam | 0.46 | 0.55 |
| SD:pam | 0.43 | 0.53 |
| MAD:hclust | 0.24 | 0.44 |
| ATC:hclust | 0.48 | 0.42 |
| SD:hclust | 0.24 | 0.42 |
| SD:NMF | 0.58 | 0.41 |
| CV:hclust | 0.23 | 0.38 |
| MAD:NMF | 0.48 | 0.38 |
| CV:NMF | 0.56 | 0.37 |
| ATC:NMF | 0.64 | 0.37 |
| ATC:mclust | 0.38 | 0.3 |
Figure 1A. Consensus heatmaps with three groups. Matrix rows are scaled.
Figure 1B. Consensus heatmaps with three groups. Matrix rows are unscaled.
We pick the three-group classification from ATC:skmeans for the scaled case because it is the only stable partition, and pick SD:skmeans for the unscaled case because it has the highest 1-PAC score although it is not a stable partition. Besides the AML/ALL annotation, the original Golub study also provides B-cell/T-cell annotation for the ALL samples. The cola classifications and the annotations are visualized in Figure 2.
Figure 2. Conseusus partitions from ATC:skmeans and SD:skmeans methods.
To make it easier to describe, we term the classification from the scaled matrix as \(C_{s, 3}\) (or C_{s,3} if it cannot be rendered as math symbols) and the classification from the unscaled matrix as \(C_{u,3}\) (or C_{u,3}).
In Figure 2, we can observe that both classification \(C_{s, 3}\) and \(C_{u, 3}\) separate ALL samples into two groups, but the classifications are different. \(C_{u,3}\) separates ALL samples into two groups that fit very well with the B-cell/T-cell annotation while \(C_{s, 3}\) gives a new classification. Note in the Golub study, the B-cell/T-cell classification on ALL samples were based on SOM on the unscaled matrix, so it is expected that \(C_{u,3}\) agrees on the B-cell/T-cell classification, also there were no stability accessment on the classification in the original study.
In the PCA plots in Fgiure 3, all three groups are separated very well under \(C_{s, 3}\), while group 2 and group3 can hardly be separated under \(C_{u, 3}\).
Figure 3. PCA plots for visualizing the two-group classification. Classification on the left plot is from \(C_{s,3}\) and on the right is from \(C_{u,3}\).
Next we look at the significantly expressed genes under the two classifications, illustrated in Figure 4. Both classifications give amount of sigature genes, which is mainly due to the difference between ALL and AML. To see how different methods affect the classifiction on ALL samples, we should only look at the ALL samples, as described in the next section.
Figure 4A. Signature genes from C_{s,3}.
Figure 4B. Signature genes from C_{u,3}.
We remove the samples with class label 1 (which corresponds to AML samples) in both classifications, and we apply t-test between group 2 and group 3 samples. The significant genes under the two classifications are visualized as heatmaps in Figure 5.
Since now we only look at the two groups in the two classifications, we modify the symbols of the two classification to \(C^{(2)}_{s,3}\) and \(C^{(2)}_{u,3}\).
A direct conclusion from Figure 5 is there are far more significant genes under \(C^{(2)}_{s,3}\) (1217 genes) than \(C^{(2)}_{u,3}\) (245 genes).
Figure 5. Significant genes between group 2 and 3 in the two classifications. Left: from \(C^{(2)}_{s,3}\), right: from \(C^{(2)}_{u,3}\).
Since Figure 5 only shows the relative expression (the scaled expression), in Figure 6, we check the distribution of the absolute expression level of the signature genes in the two classifications, visualized in Figure 6. Figure 6 shows both signature genes are more enriched in the highly expressed genes, where signatures from \(C^{(2)}_{s,3}\) also cover genes with moderate expression levels.
Figure 6. Distribution of the absolute expression of signature genes. A and C: genes are ordered based on their base mean (mean expression among all samples) where significant genes are marked in blue and red. B and D: number of signatures that fall in every 20-gene interval, the same ordering on x-axes as Figure A and C.
The two sets of signature genes have very small overlap, illustrated in Figure 7.
Figure 7. Overlap of signature genes in \(C^{(2)}_{s,3}\) and \(C^{(2)}_{u,3}\).
Similar as the analysis in the two-group classification, we check the biological functions that are enriched in the two sets of signature genes from \(C^{(2)}_{s,3}\) and \(C^{(2)}_{u,3}\). Mainly because of the high amount of signature genes from \(C^{(2)}_{s,3}\), it has far more enriched GO functions than \(C^{(2)}_{u,3}\) (Figure 8).
Figure 8. Gene ontology enrichment on the two sets of signature genes illustrated in Figure 5.
As conclusions, it seems the classification from \(C^{(2)}_{s,3}\) is more reasonable because there are many signature genes as well as enriched biolofical functions, which might provide a new and different view to the B-cell/T-cell classification.
| ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | Count |
|---|---|---|---|---|---|---|
| GO:0009725 | response to hormone | 108/966 | 920/17913 | 0e+00 | 0.0000 | 108 |
| GO:0010243 | response to organonitrogen compound | 107/966 | 932/17913 | 0e+00 | 0.0000 | 107 |
| GO:1901699 | cellular response to nitrogen compound | 80/966 | 620/17913 | 0e+00 | 0.0000 | 80 |
| GO:0071417 | cellular response to organonitrogen compound | 73/966 | 559/17913 | 0e+00 | 0.0000 | 73 |
| GO:0044419 | interspecies interaction between organisms | 102/966 | 928/17913 | 0e+00 | 0.0000 | 102 |
| GO:0016071 | mRNA metabolic process | 92/966 | 815/17913 | 0e+00 | 0.0000 | 92 |
| GO:0007167 | enzyme linked receptor protein signaling pathway | 103/966 | 968/17913 | 0e+00 | 0.0000 | 103 |
| GO:0014070 | response to organic cyclic compound | 96/966 | 879/17913 | 0e+00 | 0.0000 | 96 |
| GO:0033993 | response to lipid | 96/966 | 884/17913 | 0e+00 | 0.0000 | 96 |
| GO:0044403 | symbiont process | 96/966 | 884/17913 | 0e+00 | 0.0000 | 96 |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 79/966 | 669/17913 | 0e+00 | 0.0000 | 79 |
| GO:0051050 | positive regulation of transport | 100/966 | 942/17913 | 0e+00 | 0.0000 | 100 |
| GO:0032870 | cellular response to hormone stimulus | 77/966 | 647/17913 | 0e+00 | 0.0000 | 77 |
| GO:0042493 | response to drug | 101/966 | 958/17913 | 0e+00 | 0.0000 | 101 |
| GO:0019725 | cellular homeostasis | 90/966 | 814/17913 | 0e+00 | 0.0000 | 90 |
| GO:0016032 | viral process | 90/966 | 822/17913 | 0e+00 | 0.0000 | 90 |
| GO:1901652 | response to peptide | 61/966 | 491/17913 | 0e+00 | 0.0000 | 61 |
| GO:0009894 | regulation of catabolic process | 94/966 | 916/17913 | 0e+00 | 0.0000 | 94 |
| GO:0036293 | response to decreased oxygen levels | 50/966 | 365/17913 | 0e+00 | 0.0000 | 50 |
| GO:0001666 | response to hypoxia | 49/966 | 354/17913 | 0e+00 | 0.0000 | 49 |
| GO:0070482 | response to oxygen levels | 52/966 | 389/17913 | 0e+00 | 0.0000 | 52 |
| GO:0008380 | RNA splicing | 56/966 | 440/17913 | 0e+00 | 0.0000 | 56 |
| GO:0031329 | regulation of cellular catabolic process | 85/966 | 814/17913 | 0e+00 | 0.0000 | 85 |
| GO:1901653 | cellular response to peptide | 49/966 | 364/17913 | 0e+00 | 0.0000 | 49 |
| GO:0019221 | cytokine-mediated signaling pathway | 81/966 | 764/17913 | 0e+00 | 0.0000 | 81 |
| GO:0042327 | positive regulation of phosphorylation | 95/966 | 955/17913 | 0e+00 | 0.0000 | 95 |
| GO:0048534 | hematopoietic or lymphoid organ development | 90/966 | 890/17913 | 0e+00 | 0.0000 | 90 |
| GO:0009611 | response to wounding | 73/966 | 665/17913 | 0e+00 | 0.0000 | 73 |
| GO:0000165 | MAPK cascade | 89/966 | 882/17913 | 0e+00 | 0.0000 | 89 |
| GO:0051169 | nuclear transport | 43/966 | 305/17913 | 0e+00 | 0.0000 | 43 |
| GO:0002520 | immune system development | 93/966 | 938/17913 | 0e+00 | 0.0000 | 93 |
| GO:0023014 | signal transduction by protein phosphorylation | 89/966 | 886/17913 | 0e+00 | 0.0000 | 89 |
| GO:0043620 | regulation of DNA-templated transcription in response to stress | 24/966 | 115/17913 | 0e+00 | 0.0000 | 24 |
| GO:1903311 | regulation of mRNA metabolic process | 40/966 | 275/17913 | 0e+00 | 0.0000 | 40 |
| GO:1903530 | regulation of secretion by cell | 75/966 | 703/17913 | 0e+00 | 0.0000 | 75 |
| GO:0051046 | regulation of secretion | 79/966 | 757/17913 | 0e+00 | 0.0000 | 79 |
| GO:0055082 | cellular chemical homeostasis | 72/966 | 666/17913 | 0e+00 | 0.0000 | 72 |
| GO:0006913 | nucleocytoplasmic transport | 42/966 | 302/17913 | 0e+00 | 0.0000 | 42 |
| GO:0000375 | RNA splicing, via transesterification reactions | 46/966 | 348/17913 | 0e+00 | 0.0000 | 46 |
| GO:0006886 | intracellular protein transport | 84/966 | 833/17913 | 0e+00 | 0.0000 | 84 |
| GO:0030097 | hemopoiesis | 85/966 | 847/17913 | 0e+00 | 0.0000 | 85 |
| GO:0007417 | central nervous system development | 91/966 | 935/17913 | 0e+00 | 0.0000 | 91 |
| GO:0006397 | mRNA processing | 58/966 | 499/17913 | 0e+00 | 0.0000 | 58 |
| GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 45/966 | 344/17913 | 0e+00 | 0.0000 | 45 |
| GO:0000398 | mRNA splicing, via spliceosome | 45/966 | 344/17913 | 0e+00 | 0.0000 | 45 |
| GO:0048511 | rhythmic process | 40/966 | 287/17913 | 0e+00 | 0.0000 | 40 |
| GO:0033238 | regulation of cellular amine metabolic process | 19/966 | 80/17913 | 0e+00 | 0.0000 | 19 |
| GO:0060341 | regulation of cellular localization | 85/966 | 863/17913 | 0e+00 | 0.0000 | 85 |
| GO:0001934 | positive regulation of protein phosphorylation | 88/966 | 907/17913 | 0e+00 | 0.0000 | 88 |
| GO:0048732 | gland development | 51/966 | 422/17913 | 0e+00 | 0.0000 | 51 |
| GO:0043618 | regulation of transcription from RNA polymerase II promoter in response to stress | 22/966 | 109/17913 | 0e+00 | 0.0000 | 22 |
| GO:0060322 | head development | 75/966 | 738/17913 | 0e+00 | 0.0000 | 75 |
| GO:0033674 | positive regulation of kinase activity | 60/966 | 541/17913 | 0e+00 | 0.0000 | 60 |
| GO:0006887 | exocytosis | 84/966 | 862/17913 | 0e+00 | 0.0000 | 84 |
| GO:0046883 | regulation of hormone secretion | 36/966 | 254/17913 | 0e+00 | 0.0000 | 36 |
| GO:0050852 | T cell receptor signaling pathway | 29/966 | 180/17913 | 0e+00 | 0.0000 | 29 |
| GO:0023061 | signal release | 51/966 | 433/17913 | 0e+00 | 0.0000 | 51 |
| GO:1905330 | regulation of morphogenesis of an epithelium | 29/966 | 181/17913 | 0e+00 | 0.0000 | 29 |
| GO:0090087 | regulation of peptide transport | 72/966 | 706/17913 | 0e+00 | 0.0000 | 72 |
| GO:0002444 | myeloid leukocyte mediated immunity | 60/966 | 549/17913 | 0e+00 | 0.0000 | 60 |
| GO:0043069 | negative regulation of programmed cell death | 87/966 | 916/17913 | 0e+00 | 0.0000 | 87 |
| GO:0048545 | response to steroid hormone | 46/966 | 375/17913 | 0e+00 | 0.0000 | 46 |
| GO:0098657 | import into cell | 75/966 | 751/17913 | 0e+00 | 0.0000 | 75 |
| GO:0002283 | neutrophil activation involved in immune response | 55/966 | 488/17913 | 0e+00 | 0.0000 | 55 |
| GO:0050778 | positive regulation of immune response | 79/966 | 809/17913 | 0e+00 | 0.0000 | 79 |
| GO:0043066 | negative regulation of apoptotic process | 85/966 | 894/17913 | 0e+00 | 0.0000 | 85 |
| GO:2000027 | regulation of animal organ morphogenesis | 35/966 | 250/17913 | 0e+00 | 0.0000 | 35 |
| GO:0043434 | response to peptide hormone | 48/966 | 404/17913 | 0e+00 | 0.0000 | 48 |
| GO:0051347 | positive regulation of transferase activity | 64/966 | 609/17913 | 0e+00 | 0.0000 | 64 |
| GO:0051098 | regulation of binding | 45/966 | 368/17913 | 0e+00 | 0.0000 | 45 |
| GO:0071375 | cellular response to peptide hormone stimulus | 39/966 | 297/17913 | 0e+00 | 0.0000 | 39 |
| GO:0006457 | protein folding | 28/966 | 176/17913 | 0e+00 | 0.0000 | 28 |
| GO:0007409 | axonogenesis | 47/966 | 393/17913 | 0e+00 | 0.0000 | 47 |
| GO:0009266 | response to temperature stimulus | 32/966 | 219/17913 | 0e+00 | 0.0000 | 32 |
| GO:0006836 | neurotransmitter transport | 34/966 | 241/17913 | 0e+00 | 0.0000 | 34 |
| GO:0030072 | peptide hormone secretion | 34/966 | 241/17913 | 0e+00 | 0.0000 | 34 |
| GO:0032101 | regulation of response to external stimulus | 83/966 | 873/17913 | 0e+00 | 0.0000 | 83 |
| GO:0007420 | brain development | 70/966 | 694/17913 | 0e+00 | 0.0000 | 70 |
| GO:0090276 | regulation of peptide hormone secretion | 30/966 | 199/17913 | 0e+00 | 0.0000 | 30 |
| GO:0009308 | amine metabolic process | 23/966 | 128/17913 | 0e+00 | 0.0000 | 23 |
| GO:0006974 | cellular response to DNA damage stimulus | 77/966 | 791/17913 | 0e+00 | 0.0000 | 77 |
| GO:0008015 | blood circulation | 57/966 | 523/17913 | 0e+00 | 0.0000 | 57 |
| GO:0009408 | response to heat | 26/966 | 158/17913 | 0e+00 | 0.0000 | 26 |
| GO:0043488 | regulation of mRNA stability | 26/966 | 158/17913 | 0e+00 | 0.0000 | 26 |
| GO:0017144 | drug metabolic process | 77/966 | 792/17913 | 0e+00 | 0.0000 | 77 |
| GO:0043312 | neutrophil degranulation | 54/966 | 485/17913 | 0e+00 | 0.0000 | 54 |
| GO:0046879 | hormone secretion | 39/966 | 301/17913 | 0e+00 | 0.0000 | 39 |
| GO:0002446 | neutrophil mediated immunity | 55/966 | 499/17913 | 0e+00 | 0.0000 | 55 |
| GO:0042119 | neutrophil activation | 55/966 | 499/17913 | 0e+00 | 0.0000 | 55 |
| GO:0050878 | regulation of body fluid levels | 55/966 | 499/17913 | 0e+00 | 0.0000 | 55 |
| GO:0061564 | axon development | 50/966 | 438/17913 | 0e+00 | 0.0000 | 50 |
| GO:0050851 | antigen receptor-mediated signaling pathway | 32/966 | 224/17913 | 0e+00 | 0.0000 | 32 |
| GO:0010720 | positive regulation of cell development | 57/966 | 528/17913 | 0e+00 | 0.0000 | 57 |
| GO:0044106 | cellular amine metabolic process | 22/966 | 121/17913 | 0e+00 | 0.0000 | 22 |
| GO:0043408 | regulation of MAPK cascade | 69/966 | 689/17913 | 0e+00 | 0.0000 | 69 |
| GO:0044706 | multi-multicellular organism process | 32/966 | 225/17913 | 0e+00 | 0.0000 | 32 |
| GO:0001101 | response to acid chemical | 41/966 | 330/17913 | 0e+00 | 0.0000 | 41 |
| GO:0030003 | cellular cation homeostasis | 56/966 | 518/17913 | 0e+00 | 0.0000 | 56 |
| GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 17/966 | 77/17913 | 0e+00 | 0.0000 | 17 |
| GO:0003013 | circulatory system process | 57/966 | 532/17913 | 0e+00 | 0.0000 | 57 |
| GO:0036230 | granulocyte activation | 55/966 | 506/17913 | 0e+00 | 0.0000 | 55 |
| GO:0043269 | regulation of ion transport | 65/966 | 639/17913 | 0e+00 | 0.0000 | 65 |
| GO:0043487 | regulation of RNA stability | 26/966 | 163/17913 | 0e+00 | 0.0000 | 26 |
| GO:0009887 | animal organ morphogenesis | 90/966 | 989/17913 | 0e+00 | 0.0000 | 90 |
| GO:0071396 | cellular response to lipid | 60/966 | 576/17913 | 0e+00 | 0.0000 | 60 |
| GO:0045087 | innate immune response | 83/966 | 893/17913 | 0e+00 | 0.0000 | 83 |
| GO:0009914 | hormone transport | 39/966 | 311/17913 | 0e+00 | 0.0000 | 39 |
| GO:0051170 | import into nucleus | 22/966 | 125/17913 | 0e+00 | 0.0000 | 22 |
| GO:0080135 | regulation of cellular response to stress | 70/966 | 713/17913 | 0e+00 | 0.0000 | 70 |
| GO:0035567 | non-canonical Wnt signaling pathway | 24/966 | 145/17913 | 0e+00 | 0.0000 | 24 |
| GO:0019884 | antigen processing and presentation of exogenous antigen | 27/966 | 176/17913 | 0e+00 | 0.0000 | 27 |
| GO:0097190 | apoptotic signaling pathway | 60/966 | 579/17913 | 0e+00 | 0.0000 | 60 |
| GO:0033365 | protein localization to organelle | 76/966 | 798/17913 | 0e+00 | 0.0000 | 76 |
| GO:0002253 | activation of immune response | 65/966 | 647/17913 | 0e+00 | 0.0000 | 65 |
| GO:0045860 | positive regulation of protein kinase activity | 54/966 | 501/17913 | 0e+00 | 0.0000 | 54 |
| GO:0003006 | developmental process involved in reproduction | 65/966 | 649/17913 | 0e+00 | 0.0001 | 65 |
| GO:0002275 | myeloid cell activation involved in immune response | 57/966 | 542/17913 | 0e+00 | 0.0001 | 57 |
| GO:0002790 | peptide secretion | 60/966 | 582/17913 | 0e+00 | 0.0001 | 60 |
| GO:0015696 | ammonium transport | 17/966 | 81/17913 | 0e+00 | 0.0001 | 17 |
| GO:0006873 | cellular ion homeostasis | 56/966 | 531/17913 | 0e+00 | 0.0001 | 56 |
| GO:0043299 | leukocyte degranulation | 56/966 | 532/17913 | 0e+00 | 0.0001 | 56 |
| GO:0045597 | positive regulation of cell differentiation | 87/966 | 962/17913 | 0e+00 | 0.0001 | 87 |
| GO:0050769 | positive regulation of neurogenesis | 50/966 | 455/17913 | 0e+00 | 0.0001 | 50 |
| GO:0070201 | regulation of establishment of protein localization | 70/966 | 723/17913 | 0e+00 | 0.0001 | 70 |
| GO:0040008 | regulation of growth | 66/966 | 668/17913 | 0e+00 | 0.0001 | 66 |
| GO:0006259 | DNA metabolic process | 87/966 | 964/17913 | 0e+00 | 0.0001 | 87 |
| GO:0032880 | regulation of protein localization | 88/966 | 979/17913 | 0e+00 | 0.0001 | 88 |
| GO:0043549 | regulation of kinase activity | 76/966 | 808/17913 | 0e+00 | 0.0001 | 76 |
| GO:0055080 | cation homeostasis | 60/966 | 588/17913 | 0e+00 | 0.0001 | 60 |
| GO:0071453 | cellular response to oxygen levels | 32/966 | 237/17913 | 0e+00 | 0.0001 | 32 |
| GO:0045055 | regulated exocytosis | 73/966 | 768/17913 | 0e+00 | 0.0001 | 73 |
| GO:1901361 | organic cyclic compound catabolic process | 67/966 | 685/17913 | 0e+00 | 0.0001 | 67 |
| GO:0007565 | female pregnancy | 28/966 | 193/17913 | 0e+00 | 0.0001 | 28 |
| GO:0001819 | positive regulation of cytokine production | 49/966 | 446/17913 | 0e+00 | 0.0001 | 49 |
| GO:0009991 | response to extracellular stimulus | 53/966 | 498/17913 | 0e+00 | 0.0001 | 53 |
| GO:0009755 | hormone-mediated signaling pathway | 30/966 | 216/17913 | 0e+00 | 0.0001 | 30 |
| GO:0009636 | response to toxic substance | 53/966 | 499/17913 | 0e+00 | 0.0001 | 53 |
| GO:0051100 | negative regulation of binding | 25/966 | 162/17913 | 0e+00 | 0.0001 | 25 |
| GO:0032868 | response to insulin | 33/966 | 252/17913 | 0e+00 | 0.0001 | 33 |
| GO:0002478 | antigen processing and presentation of exogenous peptide antigen | 26/966 | 174/17913 | 0e+00 | 0.0001 | 26 |
| GO:0009895 | negative regulation of catabolic process | 36/966 | 288/17913 | 0e+00 | 0.0001 | 36 |
| GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | 17/966 | 85/17913 | 0e+00 | 0.0001 | 17 |
| GO:0048608 | reproductive structure development | 47/966 | 426/17913 | 0e+00 | 0.0001 | 47 |
| GO:0034655 | nucleobase-containing compound catabolic process | 60/966 | 598/17913 | 0e+00 | 0.0001 | 60 |
| GO:0034976 | response to endoplasmic reticulum stress | 33/966 | 254/17913 | 0e+00 | 0.0001 | 33 |
| GO:0006352 | DNA-templated transcription, initiation | 31/966 | 231/17913 | 0e+00 | 0.0001 | 31 |
| GO:0019882 | antigen processing and presentation | 30/966 | 220/17913 | 0e+00 | 0.0001 | 30 |
| GO:0036294 | cellular response to decreased oxygen levels | 30/966 | 220/17913 | 0e+00 | 0.0001 | 30 |
| GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 18/966 | 95/17913 | 0e+00 | 0.0001 | 18 |
| GO:0031667 | response to nutrient levels | 50/966 | 466/17913 | 0e+00 | 0.0001 | 50 |
| GO:0098771 | inorganic ion homeostasis | 60/966 | 600/17913 | 0e+00 | 0.0001 | 60 |
| GO:0046700 | heterocycle catabolic process | 63/966 | 641/17913 | 0e+00 | 0.0001 | 63 |
| GO:0071407 | cellular response to organic cyclic compound | 55/966 | 533/17913 | 0e+00 | 0.0001 | 55 |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 39/966 | 328/17913 | 0e+00 | 0.0001 | 39 |
| GO:0071456 | cellular response to hypoxia | 29/966 | 210/17913 | 0e+00 | 0.0001 | 29 |
| GO:0061458 | reproductive system development | 47/966 | 429/17913 | 0e+00 | 0.0001 | 47 |
| GO:0050767 | regulation of neurogenesis | 72/966 | 768/17913 | 0e+00 | 0.0001 | 72 |
| GO:0048002 | antigen processing and presentation of peptide antigen | 27/966 | 188/17913 | 0e+00 | 0.0001 | 27 |
| GO:0006521 | regulation of cellular amino acid metabolic process | 14/966 | 61/17913 | 0e+00 | 0.0001 | 14 |
| GO:0002764 | immune response-regulating signaling pathway | 60/966 | 603/17913 | 0e+00 | 0.0001 | 60 |
| GO:0061013 | regulation of mRNA catabolic process | 26/966 | 178/17913 | 0e+00 | 0.0001 | 26 |
| GO:0034504 | protein localization to nucleus | 30/966 | 223/17913 | 0e+00 | 0.0001 | 30 |
| GO:0007568 | aging | 38/966 | 318/17913 | 0e+00 | 0.0001 | 38 |
| GO:0008284 | positive regulation of cell proliferation | 83/966 | 931/17913 | 0e+00 | 0.0001 | 83 |
| GO:0048729 | tissue morphogenesis | 62/966 | 635/17913 | 0e+00 | 0.0001 | 62 |
| GO:0016579 | protein deubiquitination | 33/966 | 260/17913 | 0e+00 | 0.0001 | 33 |
| GO:0002757 | immune response-activating signal transduction | 57/966 | 567/17913 | 0e+00 | 0.0001 | 57 |
| GO:0030522 | intracellular receptor signaling pathway | 34/966 | 272/17913 | 0e+00 | 0.0001 | 34 |
| GO:0034612 | response to tumor necrosis factor | 35/966 | 284/17913 | 0e+00 | 0.0001 | 35 |
| GO:0045859 | regulation of protein kinase activity | 69/966 | 733/17913 | 0e+00 | 0.0001 | 69 |
| GO:0048863 | stem cell differentiation | 31/966 | 237/17913 | 0e+00 | 0.0002 | 31 |
| GO:0001505 | regulation of neurotransmitter levels | 38/966 | 321/17913 | 0e+00 | 0.0002 | 38 |
| GO:0070646 | protein modification by small protein removal | 34/966 | 273/17913 | 0e+00 | 0.0002 | 34 |
| GO:0002274 | myeloid leukocyte activation | 63/966 | 652/17913 | 0e+00 | 0.0002 | 63 |
| GO:0031175 | neuron projection development | 79/966 | 879/17913 | 0e+00 | 0.0002 | 79 |
| GO:0042593 | glucose homeostasis | 30/966 | 227/17913 | 0e+00 | 0.0002 | 30 |
| GO:0008285 | negative regulation of cell proliferation | 70/966 | 751/17913 | 0e+00 | 0.0002 | 70 |
| GO:1902036 | regulation of hematopoietic stem cell differentiation | 15/966 | 72/17913 | 0e+00 | 0.0002 | 15 |
| GO:0031145 | anaphase-promoting complex-dependent catabolic process | 16/966 | 81/17913 | 0e+00 | 0.0002 | 16 |
| GO:0033500 | carbohydrate homeostasis | 30/966 | 228/17913 | 0e+00 | 0.0002 | 30 |
| GO:0032386 | regulation of intracellular transport | 44/966 | 400/17913 | 0e+00 | 0.0002 | 44 |
| GO:0019439 | aromatic compound catabolic process | 63/966 | 655/17913 | 0e+00 | 0.0002 | 63 |
| GO:0044270 | cellular nitrogen compound catabolic process | 62/966 | 642/17913 | 0e+00 | 0.0002 | 62 |
| GO:0099536 | synaptic signaling | 59/966 | 601/17913 | 0e+00 | 0.0002 | 59 |
| GO:0060627 | regulation of vesicle-mediated transport | 50/966 | 480/17913 | 0e+00 | 0.0002 | 50 |
| GO:0006875 | cellular metal ion homeostasis | 49/966 | 467/17913 | 0e+00 | 0.0002 | 49 |
| GO:0001944 | vasculature development | 72/966 | 784/17913 | 0e+00 | 0.0002 | 72 |
| GO:0030163 | protein catabolic process | 73/966 | 799/17913 | 0e+00 | 0.0002 | 73 |
| GO:0002443 | leukocyte mediated immunity | 74/966 | 814/17913 | 0e+00 | 0.0002 | 74 |
| GO:0051090 | regulation of DNA-binding transcription factor activity | 46/966 | 429/17913 | 0e+00 | 0.0002 | 46 |
| GO:0001525 | angiogenesis | 57/966 | 576/17913 | 0e+00 | 0.0002 | 57 |
| GO:0043270 | positive regulation of ion transport | 33/966 | 266/17913 | 0e+00 | 0.0002 | 33 |
| GO:0071356 | cellular response to tumor necrosis factor | 33/966 | 266/17913 | 0e+00 | 0.0002 | 33 |
| GO:0000904 | cell morphogenesis involved in differentiation | 61/966 | 632/17913 | 0e+00 | 0.0002 | 61 |
| GO:0002791 | regulation of peptide secretion | 50/966 | 483/17913 | 0e+00 | 0.0002 | 50 |
| GO:0000902 | cell morphogenesis | 78/966 | 874/17913 | 0e+00 | 0.0002 | 78 |
| GO:0032869 | cellular response to insulin stimulus | 27/966 | 197/17913 | 0e+00 | 0.0002 | 27 |
| GO:0060218 | hematopoietic stem cell differentiation | 16/966 | 83/17913 | 0e+00 | 0.0002 | 16 |
| GO:0032735 | positive regulation of interleukin-12 production | 10/966 | 34/17913 | 0e+00 | 0.0002 | 10 |
| GO:0051223 | regulation of protein transport | 64/966 | 677/17913 | 0e+00 | 0.0002 | 64 |
| GO:0045333 | cellular respiration | 25/966 | 176/17913 | 0e+00 | 0.0003 | 25 |
| GO:0019373 | epoxygenase P450 pathway | 6/966 | 11/17913 | 0e+00 | 0.0003 | 6 |
| GO:0060284 | regulation of cell development | 79/966 | 893/17913 | 0e+00 | 0.0003 | 79 |
| GO:0072358 | cardiovascular system development | 72/966 | 792/17913 | 0e+00 | 0.0003 | 72 |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 15/966 | 75/17913 | 0e+00 | 0.0003 | 15 |
| GO:0045664 | regulation of neuron differentiation | 59/966 | 609/17913 | 0e+00 | 0.0003 | 59 |
| GO:0048667 | cell morphogenesis involved in neuron differentiation | 51/966 | 500/17913 | 0e+00 | 0.0003 | 51 |
| GO:0010498 | proteasomal protein catabolic process | 42/966 | 382/17913 | 0e+00 | 0.0003 | 42 |
| GO:0010948 | negative regulation of cell cycle process | 39/966 | 344/17913 | 0e+00 | 0.0003 | 39 |
| GO:0051047 | positive regulation of secretion | 44/966 | 409/17913 | 0e+00 | 0.0003 | 44 |
| GO:0030073 | insulin secretion | 27/966 | 200/17913 | 0e+00 | 0.0003 | 27 |
| GO:1901532 | regulation of hematopoietic progenitor cell differentiation | 16/966 | 85/17913 | 0e+00 | 0.0003 | 16 |
| GO:0033209 | tumor necrosis factor-mediated signaling pathway | 24/966 | 167/17913 | 0e+00 | 0.0003 | 24 |
| GO:0098810 | neurotransmitter reuptake | 8/966 | 22/17913 | 0e+00 | 0.0003 | 8 |
| GO:0045786 | negative regulation of cell cycle | 59/966 | 613/17913 | 0e+00 | 0.0003 | 59 |
| GO:0050801 | ion homeostasis | 63/966 | 669/17913 | 0e+00 | 0.0003 | 63 |
| GO:0055065 | metal ion homeostasis | 53/966 | 531/17913 | 0e+00 | 0.0003 | 53 |
| GO:0006520 | cellular amino acid metabolic process | 39/966 | 347/17913 | 0e+00 | 0.0003 | 39 |
| GO:0048514 | blood vessel morphogenesis | 63/966 | 670/17913 | 0e+00 | 0.0003 | 63 |
| GO:0048013 | ephrin receptor signaling pathway | 16/966 | 86/17913 | 0e+00 | 0.0003 | 16 |
| GO:0009615 | response to virus | 37/966 | 323/17913 | 0e+00 | 0.0003 | 37 |
| GO:0009060 | aerobic respiration | 14/966 | 68/17913 | 0e+00 | 0.0003 | 14 |
| GO:0030001 | metal ion transport | 72/966 | 800/17913 | 0e+00 | 0.0003 | 72 |
| GO:0043902 | positive regulation of multi-organism process | 25/966 | 180/17913 | 0e+00 | 0.0003 | 25 |
| GO:0038095 | Fc-epsilon receptor signaling pathway | 24/966 | 169/17913 | 0e+00 | 0.0003 | 24 |
| GO:0051338 | regulation of transferase activity | 79/966 | 903/17913 | 0e+00 | 0.0003 | 79 |
| GO:0046794 | transport of virus | 13/966 | 60/17913 | 0e+00 | 0.0004 | 13 |
| GO:1903706 | regulation of hemopoiesis | 48/966 | 468/17913 | 0e+00 | 0.0004 | 48 |
| GO:0035239 | tube morphogenesis | 79/966 | 905/17913 | 0e+00 | 0.0004 | 79 |
| GO:0045471 | response to ethanol | 20/966 | 127/17913 | 0e+00 | 0.0004 | 20 |
| GO:0007268 | chemical synaptic transmission | 57/966 | 591/17913 | 0e+00 | 0.0004 | 57 |
| GO:0098916 | anterograde trans-synaptic signaling | 57/966 | 591/17913 | 0e+00 | 0.0004 | 57 |
| GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 15/966 | 78/17913 | 0e+00 | 0.0004 | 15 |
| GO:1902750 | negative regulation of cell cycle G2/M phase transition | 17/966 | 97/17913 | 0e+00 | 0.0004 | 17 |
| GO:0006935 | chemotaxis | 54/966 | 551/17913 | 0e+00 | 0.0004 | 54 |
| GO:0035821 | modification of morphology or physiology of other organism | 23/966 | 160/17913 | 0e+00 | 0.0004 | 23 |
| GO:0043393 | regulation of protein binding | 28/966 | 217/17913 | 0e+00 | 0.0004 | 28 |
| GO:0009607 | response to biotic stimulus | 81/966 | 938/17913 | 0e+00 | 0.0004 | 81 |
| GO:0070555 | response to interleukin-1 | 25/966 | 183/17913 | 0e+00 | 0.0004 | 25 |
| GO:0072503 | cellular divalent inorganic cation homeostasis | 42/966 | 392/17913 | 0e+00 | 0.0004 | 42 |
| GO:0042330 | taxis | 54/966 | 553/17913 | 0e+00 | 0.0004 | 54 |
| GO:0043410 | positive regulation of MAPK cascade | 50/966 | 499/17913 | 0e+00 | 0.0004 | 50 |
| GO:0001816 | cytokine production | 69/966 | 765/17913 | 0e+00 | 0.0004 | 69 |
| GO:0001568 | blood vessel development | 68/966 | 751/17913 | 0e+00 | 0.0004 | 68 |
| GO:0099537 | trans-synaptic signaling | 57/966 | 596/17913 | 0e+00 | 0.0004 | 57 |
| GO:0006401 | RNA catabolic process | 40/966 | 368/17913 | 0e+00 | 0.0005 | 40 |
| GO:1903532 | positive regulation of secretion by cell | 41/966 | 381/17913 | 0e+00 | 0.0005 | 41 |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 45/966 | 434/17913 | 0e+00 | 0.0005 | 45 |
| GO:0006936 | muscle contraction | 38/966 | 343/17913 | 0e+00 | 0.0005 | 38 |
| GO:0051960 | regulation of nervous system development | 76/966 | 870/17913 | 0e+00 | 0.0005 | 76 |
| GO:0006091 | generation of precursor metabolites and energy | 50/966 | 502/17913 | 0e+00 | 0.0005 | 50 |
| GO:0051952 | regulation of amine transport | 14/966 | 71/17913 | 0e+00 | 0.0005 | 14 |
| GO:0097305 | response to alcohol | 29/966 | 232/17913 | 0e+00 | 0.0005 | 29 |
| GO:0031330 | negative regulation of cellular catabolic process | 30/966 | 244/17913 | 0e+00 | 0.0005 | 30 |
| GO:0006954 | inflammatory response | 70/966 | 784/17913 | 0e+00 | 0.0005 | 70 |
| GO:0001817 | regulation of cytokine production | 64/966 | 698/17913 | 0e+00 | 0.0005 | 64 |
| GO:0007548 | sex differentiation | 32/966 | 269/17913 | 0e+00 | 0.0005 | 32 |
| GO:0019226 | transmission of nerve impulse | 12/966 | 54/17913 | 0e+00 | 0.0005 | 12 |
| GO:0015672 | monovalent inorganic cation transport | 48/966 | 477/17913 | 0e+00 | 0.0005 | 48 |
| GO:0051707 | response to other organism | 78/966 | 903/17913 | 0e+00 | 0.0005 | 78 |
| GO:0040007 | growth | 81/966 | 948/17913 | 0e+00 | 0.0005 | 81 |
| GO:0051962 | positive regulation of nervous system development | 51/966 | 519/17913 | 0e+00 | 0.0006 | 51 |
| GO:0043207 | response to external biotic stimulus | 78/966 | 905/17913 | 0e+00 | 0.0006 | 78 |
| GO:0072507 | divalent inorganic cation homeostasis | 43/966 | 412/17913 | 0e+00 | 0.0006 | 43 |
| GO:0072594 | establishment of protein localization to organelle | 46/966 | 452/17913 | 0e+00 | 0.0006 | 46 |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 42/966 | 399/17913 | 0e+00 | 0.0006 | 42 |
| GO:0032615 | interleukin-12 production | 12/966 | 55/17913 | 0e+00 | 0.0006 | 12 |
| GO:0009306 | protein secretion | 53/966 | 549/17913 | 0e+00 | 0.0006 | 53 |
| GO:0043632 | modification-dependent macromolecule catabolic process | 51/966 | 522/17913 | 0e+00 | 0.0006 | 51 |
| GO:0009743 | response to carbohydrate | 28/966 | 224/17913 | 0e+00 | 0.0006 | 28 |
| GO:0044766 | multi-organism transport | 14/966 | 73/17913 | 0e+00 | 0.0006 | 14 |
| GO:1902579 | multi-organism localization | 14/966 | 73/17913 | 0e+00 | 0.0006 | 14 |
| GO:0001504 | neurotransmitter uptake | 10/966 | 39/17913 | 0e+00 | 0.0006 | 10 |
| GO:0044257 | cellular protein catabolic process | 60/966 | 648/17913 | 0e+00 | 0.0006 | 60 |
| GO:0006367 | transcription initiation from RNA polymerase II promoter | 24/966 | 178/17913 | 0e+00 | 0.0007 | 24 |
| GO:0071347 | cellular response to interleukin-1 | 22/966 | 156/17913 | 0e+00 | 0.0007 | 22 |
| GO:0044057 | regulation of system process | 56/966 | 594/17913 | 0e+00 | 0.0007 | 56 |
| GO:0006606 | protein import into nucleus | 17/966 | 103/17913 | 0e+00 | 0.0007 | 17 |
| GO:0048524 | positive regulation of viral process | 17/966 | 103/17913 | 0e+00 | 0.0007 | 17 |
| GO:0031347 | regulation of defense response | 76/966 | 885/17913 | 0e+00 | 0.0008 | 76 |
| GO:0002009 | morphogenesis of an epithelium | 51/966 | 527/17913 | 0e+00 | 0.0008 | 51 |
| GO:0015980 | energy derivation by oxidation of organic compounds | 31/966 | 264/17913 | 0e+00 | 0.0008 | 31 |
| GO:0050796 | regulation of insulin secretion | 23/966 | 169/17913 | 0e+00 | 0.0008 | 23 |
| GO:0048024 | regulation of mRNA splicing, via spliceosome | 14/966 | 75/17913 | 0e+00 | 0.0008 | 14 |
| GO:0046677 | response to antibiotic | 36/966 | 328/17913 | 0e+00 | 0.0008 | 36 |
| GO:0075733 | intracellular transport of virus | 12/966 | 57/17913 | 0e+00 | 0.0008 | 12 |
| GO:0002366 | leukocyte activation involved in immune response | 62/966 | 684/17913 | 0e+00 | 0.0008 | 62 |
| GO:0043484 | regulation of RNA splicing | 18/966 | 115/17913 | 0e+00 | 0.0008 | 18 |
| GO:0006281 | DNA repair | 49/966 | 502/17913 | 0e+00 | 0.0009 | 49 |
| GO:0038093 | Fc receptor signaling pathway | 29/966 | 241/17913 | 0e+00 | 0.0009 | 29 |
| GO:0051954 | positive regulation of amine transport | 9/966 | 33/17913 | 0e+00 | 0.0009 | 9 |
| GO:0045666 | positive regulation of neuron differentiation | 38/966 | 355/17913 | 0e+00 | 0.0009 | 38 |
| GO:0050770 | regulation of axonogenesis | 21/966 | 148/17913 | 0e+00 | 0.0009 | 21 |
| GO:2000736 | regulation of stem cell differentiation | 18/966 | 116/17913 | 0e+00 | 0.0009 | 18 |
| GO:0015837 | amine transport | 14/966 | 76/17913 | 0e+00 | 0.0009 | 14 |
| GO:0034622 | cellular protein-containing complex assembly | 80/966 | 952/17913 | 0e+00 | 0.0010 | 80 |
| GO:0002263 | cell activation involved in immune response | 62/966 | 688/17913 | 0e+00 | 0.0010 | 62 |
| GO:0071383 | cellular response to steroid hormone stimulus | 29/966 | 243/17913 | 1e-04 | 0.0010 | 29 |
| GO:2001233 | regulation of apoptotic signaling pathway | 41/966 | 397/17913 | 1e-04 | 0.0010 | 41 |
| GO:0018105 | peptidyl-serine phosphorylation | 28/966 | 231/17913 | 1e-04 | 0.0010 | 28 |
| GO:0006897 | endocytosis | 61/966 | 675/17913 | 1e-04 | 0.0010 | 61 |
| GO:0034605 | cellular response to heat | 18/966 | 117/17913 | 1e-04 | 0.0010 | 18 |
| GO:0030099 | myeloid cell differentiation | 42/966 | 411/17913 | 1e-04 | 0.0010 | 42 |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | 17/966 | 107/17913 | 1e-04 | 0.0011 | 17 |
| GO:0006403 | RNA localization | 26/966 | 208/17913 | 1e-04 | 0.0011 | 26 |
| GO:0062012 | regulation of small molecule metabolic process | 44/966 | 439/17913 | 1e-04 | 0.0011 | 44 |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | 65/966 | 735/17913 | 1e-04 | 0.0011 | 65 |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | 30/966 | 257/17913 | 1e-04 | 0.0011 | 30 |
| GO:0010389 | regulation of G2/M transition of mitotic cell cycle | 24/966 | 185/17913 | 1e-04 | 0.0011 | 24 |
| GO:0098660 | inorganic ion transmembrane transport | 64/966 | 722/17913 | 1e-04 | 0.0011 | 64 |
| GO:0051588 | regulation of neurotransmitter transport | 19/966 | 129/17913 | 1e-04 | 0.0011 | 19 |
| GO:0050684 | regulation of mRNA processing | 17/966 | 108/17913 | 1e-04 | 0.0012 | 17 |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 49/966 | 510/17913 | 1e-04 | 0.0012 | 49 |
| GO:0043405 | regulation of MAP kinase activity | 35/966 | 322/17913 | 1e-04 | 0.0012 | 35 |
| GO:0032989 | cellular component morphogenesis | 80/966 | 960/17913 | 1e-04 | 0.0012 | 80 |
| GO:0055074 | calcium ion homeostasis | 40/966 | 388/17913 | 1e-04 | 0.0012 | 40 |
| GO:0006874 | cellular calcium ion homeostasis | 39/966 | 375/17913 | 1e-04 | 0.0012 | 39 |
| GO:0043065 | positive regulation of apoptotic process | 59/966 | 652/17913 | 1e-04 | 0.0012 | 59 |
| GO:0035690 | cellular response to drug | 38/966 | 362/17913 | 1e-04 | 0.0012 | 38 |
| GO:1903312 | negative regulation of mRNA metabolic process | 13/966 | 69/17913 | 1e-04 | 0.0013 | 13 |
| GO:0022407 | regulation of cell-cell adhesion | 40/966 | 389/17913 | 1e-04 | 0.0013 | 40 |
| GO:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling | 55/966 | 596/17913 | 1e-04 | 0.0013 | 55 |
| GO:0017157 | regulation of exocytosis | 24/966 | 187/17913 | 1e-04 | 0.0013 | 24 |
| GO:0090175 | regulation of establishment of planar polarity | 17/966 | 109/17913 | 1e-04 | 0.0013 | 17 |
| GO:0002064 | epithelial cell development | 25/966 | 199/17913 | 1e-04 | 0.0013 | 25 |
| GO:0006937 | regulation of muscle contraction | 22/966 | 164/17913 | 1e-04 | 0.0013 | 22 |
| GO:0051052 | regulation of DNA metabolic process | 41/966 | 403/17913 | 1e-04 | 0.0013 | 41 |
| GO:0051101 | regulation of DNA binding | 18/966 | 120/17913 | 1e-04 | 0.0013 | 18 |
| GO:0044703 | multi-organism reproductive process | 81/966 | 980/17913 | 1e-04 | 0.0014 | 81 |
| GO:0006402 | mRNA catabolic process | 36/966 | 338/17913 | 1e-04 | 0.0014 | 36 |
| GO:0034284 | response to monosaccharide | 25/966 | 200/17913 | 1e-04 | 0.0014 | 25 |
| GO:0042098 | T cell proliferation | 23/966 | 177/17913 | 1e-04 | 0.0014 | 23 |
| GO:0008361 | regulation of cell size | 21/966 | 154/17913 | 1e-04 | 0.0014 | 21 |
| GO:0019941 | modification-dependent protein catabolic process | 49/966 | 515/17913 | 1e-04 | 0.0014 | 49 |
| GO:0030100 | regulation of endocytosis | 30/966 | 262/17913 | 1e-04 | 0.0014 | 30 |
| GO:0006470 | protein dephosphorylation | 34/966 | 313/17913 | 1e-04 | 0.0014 | 34 |
| GO:0002886 | regulation of myeloid leukocyte mediated immunity | 11/966 | 52/17913 | 1e-04 | 0.0014 | 11 |
| GO:0002573 | myeloid leukocyte differentiation | 25/966 | 201/17913 | 1e-04 | 0.0014 | 25 |
| GO:0007623 | circadian rhythm | 25/966 | 201/17913 | 1e-04 | 0.0014 | 25 |
| GO:0050804 | modulation of chemical synaptic transmission | 40/966 | 393/17913 | 1e-04 | 0.0015 | 40 |
| GO:0000086 | G2/M transition of mitotic cell cycle | 28/966 | 238/17913 | 1e-04 | 0.0015 | 28 |
| GO:0045165 | cell fate commitment | 28/966 | 238/17913 | 1e-04 | 0.0015 | 28 |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 53/966 | 573/17913 | 1e-04 | 0.0015 | 53 |
| GO:0048812 | neuron projection morphogenesis | 52/966 | 559/17913 | 1e-04 | 0.0015 | 52 |
| GO:0010817 | regulation of hormone levels | 48/966 | 503/17913 | 1e-04 | 0.0015 | 48 |
| GO:0003012 | muscle system process | 44/966 | 448/17913 | 1e-04 | 0.0015 | 44 |
| GO:0051656 | establishment of organelle localization | 44/966 | 448/17913 | 1e-04 | 0.0015 | 44 |
| GO:0060560 | developmental growth involved in morphogenesis | 26/966 | 214/17913 | 1e-04 | 0.0015 | 26 |
| GO:0099177 | regulation of trans-synaptic signaling | 40/966 | 394/17913 | 1e-04 | 0.0015 | 40 |
| GO:0071363 | cellular response to growth factor stimulus | 60/966 | 674/17913 | 1e-04 | 0.0015 | 60 |
| GO:0043068 | positive regulation of programmed cell death | 59/966 | 660/17913 | 1e-04 | 0.0016 | 59 |
| GO:0030162 | regulation of proteolysis | 66/966 | 762/17913 | 1e-04 | 0.0016 | 66 |
| GO:0043900 | regulation of multi-organism process | 41/966 | 408/17913 | 1e-04 | 0.0016 | 41 |
| GO:0018209 | peptidyl-serine modification | 29/966 | 252/17913 | 1e-04 | 0.0016 | 29 |
| GO:0007584 | response to nutrient | 26/966 | 215/17913 | 1e-04 | 0.0016 | 26 |
| GO:0032147 | activation of protein kinase activity | 33/966 | 303/17913 | 1e-04 | 0.0016 | 33 |
| GO:0032655 | regulation of interleukin-12 production | 11/966 | 53/17913 | 1e-04 | 0.0016 | 11 |
| GO:0010976 | positive regulation of neuron projection development | 30/966 | 265/17913 | 1e-04 | 0.0016 | 30 |
| GO:0001736 | establishment of planar polarity | 18/966 | 123/17913 | 1e-04 | 0.0017 | 18 |
| GO:0007164 | establishment of tissue polarity | 18/966 | 123/17913 | 1e-04 | 0.0017 | 18 |
| GO:0015850 | organic hydroxy compound transport | 27/966 | 228/17913 | 1e-04 | 0.0017 | 27 |
| GO:0051650 | establishment of vesicle localization | 29/966 | 253/17913 | 1e-04 | 0.0017 | 29 |
| GO:0048858 | cell projection morphogenesis | 53/966 | 577/17913 | 1e-04 | 0.0017 | 53 |
| GO:0002888 | positive regulation of myeloid leukocyte mediated immunity | 8/966 | 29/17913 | 1e-04 | 0.0017 | 8 |
| GO:0071900 | regulation of protein serine/threonine kinase activity | 46/966 | 479/17913 | 1e-04 | 0.0017 | 46 |
| GO:0051651 | maintenance of location in cell | 13/966 | 72/17913 | 1e-04 | 0.0017 | 13 |
| GO:0007610 | behavior | 53/966 | 578/17913 | 1e-04 | 0.0018 | 53 |
| GO:0045921 | positive regulation of exocytosis | 14/966 | 82/17913 | 1e-04 | 0.0018 | 14 |
| GO:0051817 | modification of morphology or physiology of other organism involved in symbiotic interaction | 17/966 | 113/17913 | 1e-04 | 0.0018 | 17 |
| GO:0050900 | leukocyte migration | 45/966 | 467/17913 | 1e-04 | 0.0019 | 45 |
| GO:0045088 | regulation of innate immune response | 43/966 | 440/17913 | 1e-04 | 0.0019 | 43 |
| GO:0010942 | positive regulation of cell death | 62/966 | 710/17913 | 1e-04 | 0.0019 | 62 |
| GO:0060249 | anatomical structure homeostasis | 41/966 | 413/17913 | 1e-04 | 0.0019 | 41 |
| GO:0032990 | cell part morphogenesis | 54/966 | 595/17913 | 1e-04 | 0.0019 | 54 |
| GO:0046887 | positive regulation of hormone secretion | 18/966 | 125/17913 | 1e-04 | 0.0020 | 18 |
| GO:0019932 | second-messenger-mediated signaling | 37/966 | 360/17913 | 1e-04 | 0.0020 | 37 |
| GO:0070997 | neuron death | 36/966 | 347/17913 | 1e-04 | 0.0020 | 36 |
| GO:1901990 | regulation of mitotic cell cycle phase transition | 42/966 | 428/17913 | 1e-04 | 0.0020 | 42 |
| GO:0045926 | negative regulation of growth | 28/966 | 244/17913 | 1e-04 | 0.0021 | 28 |
| GO:1902600 | proton transmembrane transport | 20/966 | 148/17913 | 1e-04 | 0.0021 | 20 |
| GO:0098586 | cellular response to virus | 11/966 | 55/17913 | 1e-04 | 0.0022 | 11 |
| GO:0051272 | positive regulation of cellular component movement | 51/966 | 555/17913 | 1e-04 | 0.0022 | 51 |
| GO:0009790 | embryo development | 79/966 | 968/17913 | 1e-04 | 0.0022 | 79 |
| GO:0071902 | positive regulation of protein serine/threonine kinase activity | 34/966 | 322/17913 | 1e-04 | 0.0022 | 34 |
| GO:0002521 | leukocyte differentiation | 46/966 | 485/17913 | 1e-04 | 0.0022 | 46 |
| GO:0016572 | histone phosphorylation | 9/966 | 38/17913 | 1e-04 | 0.0022 | 9 |
| GO:0071214 | cellular response to abiotic stimulus | 33/966 | 310/17913 | 2e-04 | 0.0023 | 33 |
| GO:0104004 | cellular response to environmental stimulus | 33/966 | 310/17913 | 2e-04 | 0.0023 | 33 |
| GO:0098662 | inorganic cation transmembrane transport | 57/966 | 643/17913 | 2e-04 | 0.0023 | 57 |
| GO:0007569 | cell aging | 17/966 | 116/17913 | 2e-04 | 0.0023 | 17 |
| GO:0030155 | regulation of cell adhesion | 58/966 | 659/17913 | 2e-04 | 0.0024 | 58 |
| GO:0002758 | innate immune response-activating signal transduction | 32/966 | 298/17913 | 2e-04 | 0.0024 | 32 |
| GO:0045137 | development of primary sexual characteristics | 26/966 | 223/17913 | 2e-04 | 0.0026 | 26 |
| GO:0018279 | protein N-linked glycosylation via asparagine | 8/966 | 31/17913 | 2e-04 | 0.0026 | 8 |
| GO:0015844 | monoamine transport | 12/966 | 66/17913 | 2e-04 | 0.0027 | 12 |
| GO:0051603 | proteolysis involved in cellular protein catabolic process | 53/966 | 590/17913 | 2e-04 | 0.0027 | 53 |
| GO:0032392 | DNA geometric change | 14/966 | 86/17913 | 2e-04 | 0.0028 | 14 |
| GO:0010506 | regulation of autophagy | 33/966 | 314/17913 | 2e-04 | 0.0028 | 33 |
| GO:0060047 | heart contraction | 30/966 | 275/17913 | 2e-04 | 0.0028 | 30 |
| GO:0032890 | regulation of organic acid transport | 11/966 | 57/17913 | 2e-04 | 0.0029 | 11 |
| GO:0033119 | negative regulation of RNA splicing | 7/966 | 24/17913 | 2e-04 | 0.0029 | 7 |
| GO:0043406 | positive regulation of MAP kinase activity | 28/966 | 250/17913 | 2e-04 | 0.0029 | 28 |
| GO:0001889 | liver development | 18/966 | 130/17913 | 2e-04 | 0.0030 | 18 |
| GO:0046683 | response to organophosphorus | 18/966 | 130/17913 | 2e-04 | 0.0030 | 18 |
| GO:0090257 | regulation of muscle system process | 28/966 | 251/17913 | 2e-04 | 0.0031 | 28 |
| GO:0044772 | mitotic cell cycle phase transition | 51/966 | 565/17913 | 2e-04 | 0.0031 | 51 |
| GO:0048598 | embryonic morphogenesis | 51/966 | 565/17913 | 2e-04 | 0.0031 | 51 |
| GO:0042987 | amyloid precursor protein catabolic process | 9/966 | 40/17913 | 2e-04 | 0.0032 | 9 |
| GO:0097193 | intrinsic apoptotic signaling pathway | 30/966 | 277/17913 | 2e-04 | 0.0032 | 30 |
| GO:0001678 | cellular glucose homeostasis | 19/966 | 142/17913 | 2e-04 | 0.0032 | 19 |
| GO:0018196 | peptidyl-asparagine modification | 8/966 | 32/17913 | 2e-04 | 0.0032 | 8 |
| GO:1903047 | mitotic cell cycle process | 68/966 | 816/17913 | 2e-04 | 0.0032 | 68 |
| GO:0034762 | regulation of transmembrane transport | 49/966 | 538/17913 | 2e-04 | 0.0033 | 49 |
| GO:1902749 | regulation of cell cycle G2/M phase transition | 24/966 | 202/17913 | 2e-04 | 0.0033 | 24 |
| GO:0007187 | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | 22/966 | 178/17913 | 2e-04 | 0.0034 | 22 |
| GO:0007369 | gastrulation | 22/966 | 178/17913 | 2e-04 | 0.0034 | 22 |
| GO:0039535 | regulation of RIG-I signaling pathway | 6/966 | 18/17913 | 3e-04 | 0.0035 | 6 |
| GO:0046641 | positive regulation of alpha-beta T cell proliferation | 6/966 | 18/17913 | 3e-04 | 0.0035 | 6 |
| GO:0038061 | NIK/NF-kappaB signaling | 22/966 | 179/17913 | 3e-04 | 0.0036 | 22 |
| GO:0051236 | establishment of RNA localization | 22/966 | 179/17913 | 3e-04 | 0.0036 | 22 |
| GO:0002218 | activation of innate immune response | 33/966 | 319/17913 | 3e-04 | 0.0036 | 33 |
| GO:0048872 | homeostasis of number of cells | 27/966 | 241/17913 | 3e-04 | 0.0036 | 27 |
| GO:0015991 | ATP hydrolysis coupled proton transport | 7/966 | 25/17913 | 3e-04 | 0.0036 | 7 |
| GO:0018108 | peptidyl-tyrosine phosphorylation | 35/966 | 346/17913 | 3e-04 | 0.0036 | 35 |
| GO:0043062 | extracellular structure organization | 38/966 | 387/17913 | 3e-04 | 0.0037 | 38 |
| GO:0050434 | positive regulation of viral transcription | 9/966 | 41/17913 | 3e-04 | 0.0037 | 9 |
| GO:0042391 | regulation of membrane potential | 37/966 | 374/17913 | 3e-04 | 0.0038 | 37 |
| GO:0061008 | hepaticobiliary system development | 18/966 | 133/17913 | 3e-04 | 0.0038 | 18 |
| GO:0008406 | gonad development | 25/966 | 217/17913 | 3e-04 | 0.0038 | 25 |
| GO:0032892 | positive regulation of organic acid transport | 8/966 | 33/17913 | 3e-04 | 0.0039 | 8 |
| GO:0006353 | DNA-templated transcription, termination | 12/966 | 69/17913 | 3e-04 | 0.0039 | 12 |
| GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 12/966 | 69/17913 | 3e-04 | 0.0039 | 12 |
| GO:0046822 | regulation of nucleocytoplasmic transport | 15/966 | 100/17913 | 3e-04 | 0.0039 | 15 |
| GO:0006405 | RNA export from nucleus | 17/966 | 122/17913 | 3e-04 | 0.0039 | 17 |
| GO:0010975 | regulation of neuron projection development | 43/966 | 458/17913 | 3e-04 | 0.0039 | 43 |
| GO:0070848 | response to growth factor | 60/966 | 704/17913 | 3e-04 | 0.0040 | 60 |
| GO:0031346 | positive regulation of cell projection organization | 36/966 | 362/17913 | 3e-04 | 0.0040 | 36 |
| GO:0010564 | regulation of cell cycle process | 64/966 | 764/17913 | 3e-04 | 0.0040 | 64 |
| GO:0043401 | steroid hormone mediated signaling pathway | 22/966 | 181/17913 | 3e-04 | 0.0040 | 22 |
| GO:0051099 | positive regulation of binding | 22/966 | 181/17913 | 3e-04 | 0.0040 | 22 |
| GO:0061387 | regulation of extent of cell growth | 14/966 | 90/17913 | 3e-04 | 0.0041 | 14 |
| GO:0018212 | peptidyl-tyrosine modification | 35/966 | 349/17913 | 3e-04 | 0.0041 | 35 |
| GO:0010469 | regulation of signaling receptor activity | 52/966 | 588/17913 | 3e-04 | 0.0041 | 52 |
| GO:0007599 | hemostasis | 34/966 | 336/17913 | 3e-04 | 0.0042 | 34 |
| GO:0032479 | regulation of type I interferon production | 17/966 | 123/17913 | 3e-04 | 0.0042 | 17 |
| GO:0044839 | cell cycle G2/M phase transition | 28/966 | 257/17913 | 3e-04 | 0.0042 | 28 |
| GO:0009410 | response to xenobiotic stimulus | 29/966 | 270/17913 | 3e-04 | 0.0042 | 29 |
| GO:0051648 | vesicle localization | 29/966 | 270/17913 | 3e-04 | 0.0042 | 29 |
| GO:0048675 | axon extension | 15/966 | 101/17913 | 3e-04 | 0.0042 | 15 |
| GO:0002244 | hematopoietic progenitor cell differentiation | 20/966 | 158/17913 | 3e-04 | 0.0043 | 20 |
| GO:0043903 | regulation of symbiosis, encompassing mutualism through parasitism | 26/966 | 232/17913 | 3e-04 | 0.0043 | 26 |
| GO:0050817 | coagulation | 34/966 | 337/17913 | 3e-04 | 0.0043 | 34 |
| GO:0003015 | heart process | 30/966 | 284/17913 | 3e-04 | 0.0044 | 30 |
| GO:0015988 | energy coupled proton transmembrane transport, against electrochemical gradient | 7/966 | 26/17913 | 3e-04 | 0.0044 | 7 |
| GO:0009746 | response to hexose | 23/966 | 195/17913 | 4e-04 | 0.0044 | 23 |
| GO:0010959 | regulation of metal ion transport | 36/966 | 365/17913 | 4e-04 | 0.0045 | 36 |
| GO:0042177 | negative regulation of protein catabolic process | 17/966 | 124/17913 | 4e-04 | 0.0045 | 17 |
| GO:0048025 | negative regulation of mRNA splicing, via spliceosome | 6/966 | 19/17913 | 4e-04 | 0.0045 | 6 |
| GO:1990182 | exosomal secretion | 6/966 | 19/17913 | 4e-04 | 0.0045 | 6 |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | 16/966 | 113/17913 | 4e-04 | 0.0046 | 16 |
| GO:0048645 | animal organ formation | 11/966 | 61/17913 | 4e-04 | 0.0046 | 11 |
| GO:0015931 | nucleobase-containing compound transport | 25/966 | 221/17913 | 4e-04 | 0.0047 | 25 |
| GO:0007346 | regulation of mitotic cell cycle | 54/966 | 622/17913 | 4e-04 | 0.0047 | 54 |
| GO:1901987 | regulation of cell cycle phase transition | 43/966 | 464/17913 | 4e-04 | 0.0048 | 43 |
| GO:0051235 | maintenance of location | 30/966 | 286/17913 | 4e-04 | 0.0048 | 30 |
| GO:0032606 | type I interferon production | 17/966 | 125/17913 | 4e-04 | 0.0048 | 17 |
| GO:0042060 | wound healing | 49/966 | 550/17913 | 4e-04 | 0.0048 | 49 |
| GO:1904646 | cellular response to amyloid-beta | 9/966 | 43/17913 | 4e-04 | 0.0049 | 9 |
| GO:0032091 | negative regulation of protein binding | 15/966 | 103/17913 | 4e-04 | 0.0050 | 15 |
| GO:0044770 | cell cycle phase transition | 53/966 | 609/17913 | 4e-04 | 0.0050 | 53 |
| GO:0043254 | regulation of protein complex assembly | 39/966 | 409/17913 | 4e-04 | 0.0050 | 39 |
| GO:0042176 | regulation of protein catabolic process | 35/966 | 354/17913 | 4e-04 | 0.0050 | 35 |
| GO:0046034 | ATP metabolic process | 30/966 | 287/17913 | 4e-04 | 0.0050 | 30 |
| GO:1901991 | negative regulation of mitotic cell cycle phase transition | 26/966 | 235/17913 | 4e-04 | 0.0050 | 26 |
| GO:0006970 | response to osmotic stress | 13/966 | 82/17913 | 4e-04 | 0.0051 | 13 |
| GO:0046777 | protein autophosphorylation | 24/966 | 210/17913 | 4e-04 | 0.0051 | 24 |
| GO:0042129 | regulation of T cell proliferation | 19/966 | 149/17913 | 4e-04 | 0.0051 | 19 |
| GO:0016049 | cell growth | 43/966 | 466/17913 | 4e-04 | 0.0051 | 43 |
| GO:0050772 | positive regulation of axonogenesis | 12/966 | 72/17913 | 4e-04 | 0.0052 | 12 |
| GO:0051591 | response to cAMP | 14/966 | 93/17913 | 4e-04 | 0.0053 | 14 |
| GO:0050686 | negative regulation of mRNA processing | 7/966 | 27/17913 | 4e-04 | 0.0053 | 7 |
| GO:0099131 | ATP hydrolysis coupled ion transmembrane transport | 7/966 | 27/17913 | 4e-04 | 0.0053 | 7 |
| GO:0098655 | cation transmembrane transport | 61/966 | 730/17913 | 4e-04 | 0.0053 | 61 |
| GO:0099003 | vesicle-mediated transport in synapse | 21/966 | 174/17913 | 5e-04 | 0.0055 | 21 |
| GO:0070838 | divalent metal ion transport | 42/966 | 454/17913 | 5e-04 | 0.0056 | 42 |
| GO:0034764 | positive regulation of transmembrane transport | 23/966 | 199/17913 | 5e-04 | 0.0056 | 23 |
| GO:0050670 | regulation of lymphocyte proliferation | 23/966 | 199/17913 | 5e-04 | 0.0056 | 23 |
| GO:2000147 | positive regulation of cell motility | 48/966 | 540/17913 | 5e-04 | 0.0056 | 48 |
| GO:0034383 | low-density lipoprotein particle clearance | 9/966 | 44/17913 | 5e-04 | 0.0056 | 9 |
| GO:0039529 | RIG-I signaling pathway | 6/966 | 20/17913 | 5e-04 | 0.0057 | 6 |
| GO:0042053 | regulation of dopamine metabolic process | 6/966 | 20/17913 | 5e-04 | 0.0057 | 6 |
| GO:0042069 | regulation of catecholamine metabolic process | 6/966 | 20/17913 | 5e-04 | 0.0057 | 6 |
| GO:0097734 | extracellular exosome biogenesis | 6/966 | 20/17913 | 5e-04 | 0.0057 | 6 |
| GO:0002220 | innate immune response activating cell surface receptor signaling pathway | 16/966 | 116/17913 | 5e-04 | 0.0057 | 16 |
| GO:0071426 | ribonucleoprotein complex export from nucleus | 16/966 | 116/17913 | 5e-04 | 0.0057 | 16 |
| GO:0051129 | negative regulation of cellular component organization | 57/966 | 673/17913 | 5e-04 | 0.0057 | 57 |
| GO:0001738 | morphogenesis of a polarized epithelium | 18/966 | 139/17913 | 5e-04 | 0.0057 | 18 |
| GO:0071322 | cellular response to carbohydrate stimulus | 18/966 | 139/17913 | 5e-04 | 0.0057 | 18 |
| GO:0002697 | regulation of immune effector process | 41/966 | 441/17913 | 5e-04 | 0.0057 | 41 |
| GO:2001236 | regulation of extrinsic apoptotic signaling pathway | 19/966 | 151/17913 | 5e-04 | 0.0057 | 19 |
| GO:0006611 | protein export from nucleus | 20/966 | 163/17913 | 5e-04 | 0.0057 | 20 |
| GO:0051402 | neuron apoptotic process | 26/966 | 238/17913 | 5e-04 | 0.0057 | 26 |
| GO:0072331 | signal transduction by p53 class mediator | 28/966 | 264/17913 | 5e-04 | 0.0057 | 28 |
| GO:0032944 | regulation of mononuclear cell proliferation | 23/966 | 200/17913 | 5e-04 | 0.0058 | 23 |
| GO:0007596 | blood coagulation | 33/966 | 331/17913 | 5e-04 | 0.0058 | 33 |
| GO:0050708 | regulation of protein secretion | 42/966 | 456/17913 | 5e-04 | 0.0058 | 42 |
| GO:0046649 | lymphocyte activation | 54/966 | 630/17913 | 5e-04 | 0.0059 | 54 |
| GO:0008286 | insulin receptor signaling pathway | 17/966 | 128/17913 | 5e-04 | 0.0059 | 17 |
| GO:0006914 | autophagy | 43/966 | 471/17913 | 5e-04 | 0.0060 | 43 |
| GO:0061919 | process utilizing autophagic mechanism | 43/966 | 471/17913 | 5e-04 | 0.0060 | 43 |
| GO:0050657 | nucleic acid transport | 21/966 | 176/17913 | 5e-04 | 0.0060 | 21 |
| GO:0050658 | RNA transport | 21/966 | 176/17913 | 5e-04 | 0.0060 | 21 |
| GO:0051168 | nuclear export | 21/966 | 176/17913 | 5e-04 | 0.0060 | 21 |
| GO:0045089 | positive regulation of innate immune response | 36/966 | 373/17913 | 5e-04 | 0.0060 | 36 |
| GO:0017038 | protein import | 18/966 | 140/17913 | 5e-04 | 0.0060 | 18 |
| GO:0042110 | T cell activation | 41/966 | 443/17913 | 5e-04 | 0.0060 | 41 |
| GO:0071166 | ribonucleoprotein complex localization | 16/966 | 117/17913 | 5e-04 | 0.0060 | 16 |
| GO:1900180 | regulation of protein localization to nucleus | 16/966 | 117/17913 | 5e-04 | 0.0060 | 16 |
| GO:2001020 | regulation of response to DNA damage stimulus | 23/966 | 201/17913 | 5e-04 | 0.0060 | 23 |
| GO:1904645 | response to amyloid-beta | 10/966 | 54/17913 | 5e-04 | 0.0060 | 10 |
| GO:0006354 | DNA-templated transcription, elongation | 15/966 | 106/17913 | 6e-04 | 0.0061 | 15 |
| GO:0043200 | response to amino acid | 15/966 | 106/17913 | 6e-04 | 0.0061 | 15 |
| GO:0070663 | regulation of leukocyte proliferation | 24/966 | 214/17913 | 6e-04 | 0.0061 | 24 |
| GO:0016311 | dephosphorylation | 42/966 | 458/17913 | 6e-04 | 0.0061 | 42 |
| GO:0072511 | divalent inorganic cation transport | 42/966 | 458/17913 | 6e-04 | 0.0061 | 42 |
| GO:0030104 | water homeostasis | 12/966 | 74/17913 | 6e-04 | 0.0061 | 12 |
| GO:0032481 | positive regulation of type I interferon production | 12/966 | 74/17913 | 6e-04 | 0.0061 | 12 |
| GO:0090662 | ATP hydrolysis coupled transmembrane transport | 7/966 | 28/17913 | 6e-04 | 0.0062 | 7 |
| GO:0010463 | mesenchymal cell proliferation | 9/966 | 45/17913 | 6e-04 | 0.0062 | 9 |
| GO:0046782 | regulation of viral transcription | 11/966 | 64/17913 | 6e-04 | 0.0062 | 11 |
| GO:2000145 | regulation of cell motility | 76/966 | 966/17913 | 6e-04 | 0.0062 | 76 |
| GO:0009749 | response to glucose | 22/966 | 190/17913 | 6e-04 | 0.0065 | 22 |
| GO:0022037 | metencephalon development | 15/966 | 107/17913 | 6e-04 | 0.0066 | 15 |
| GO:0039531 | regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway | 6/966 | 21/17913 | 7e-04 | 0.0070 | 6 |
| GO:0003009 | skeletal muscle contraction | 8/966 | 37/17913 | 7e-04 | 0.0071 | 8 |
| GO:0051590 | positive regulation of neurotransmitter transport | 8/966 | 37/17913 | 7e-04 | 0.0071 | 8 |
| GO:0050792 | regulation of viral process | 23/966 | 204/17913 | 7e-04 | 0.0072 | 23 |
| GO:1901796 | regulation of signal transduction by p53 class mediator | 21/966 | 179/17913 | 7e-04 | 0.0072 | 21 |
| GO:0071326 | cellular response to monosaccharide stimulus | 17/966 | 131/17913 | 7e-04 | 0.0073 | 17 |
| GO:0061136 | regulation of proteasomal protein catabolic process | 20/966 | 167/17913 | 7e-04 | 0.0073 | 20 |
| GO:0009314 | response to radiation | 40/966 | 435/17913 | 7e-04 | 0.0076 | 40 |
| GO:0034205 | amyloid-beta formation | 7/966 | 29/17913 | 7e-04 | 0.0076 | 7 |
| GO:0070661 | leukocyte proliferation | 28/966 | 270/17913 | 7e-04 | 0.0076 | 28 |
| GO:0032508 | DNA duplex unwinding | 12/966 | 76/17913 | 7e-04 | 0.0076 | 12 |
| GO:0019058 | viral life cycle | 32/966 | 324/17913 | 7e-04 | 0.0076 | 32 |
| GO:0046651 | lymphocyte proliferation | 26/966 | 244/17913 | 7e-04 | 0.0077 | 26 |
| GO:0051924 | regulation of calcium ion transport | 26/966 | 244/17913 | 7e-04 | 0.0077 | 26 |
| GO:0033044 | regulation of chromosome organization | 31/966 | 311/17913 | 7e-04 | 0.0078 | 31 |
| GO:0050727 | regulation of inflammatory response | 43/966 | 479/17913 | 7e-04 | 0.0078 | 43 |
| GO:0021549 | cerebellum development | 14/966 | 98/17913 | 8e-04 | 0.0080 | 14 |
| GO:0048638 | regulation of developmental growth | 32/966 | 325/17913 | 8e-04 | 0.0080 | 32 |
| GO:1903827 | regulation of cellular protein localization | 45/966 | 509/17913 | 8e-04 | 0.0082 | 45 |
| GO:0008217 | regulation of blood pressure | 20/966 | 169/17913 | 8e-04 | 0.0083 | 20 |
| GO:0060401 | cytosolic calcium ion transport | 19/966 | 157/17913 | 8e-04 | 0.0084 | 19 |
| GO:0002262 | myeloid cell homeostasis | 18/966 | 145/17913 | 8e-04 | 0.0084 | 18 |
| GO:0014074 | response to purine-containing compound | 18/966 | 145/17913 | 8e-04 | 0.0084 | 18 |
| GO:0060402 | calcium ion transport into cytosol | 18/966 | 145/17913 | 8e-04 | 0.0084 | 18 |
| GO:0032943 | mononuclear cell proliferation | 26/966 | 246/17913 | 8e-04 | 0.0085 | 26 |
| GO:0001558 | regulation of cell growth | 37/966 | 396/17913 | 8e-04 | 0.0085 | 37 |
| GO:1903708 | positive regulation of hemopoiesis | 21/966 | 182/17913 | 8e-04 | 0.0086 | 21 |
| GO:0019430 | removal of superoxide radicals | 6/966 | 22/17913 | 9e-04 | 0.0087 | 6 |
| GO:0043302 | positive regulation of leukocyte degranulation | 6/966 | 22/17913 | 9e-04 | 0.0087 | 6 |
| GO:0140112 | extracellular vesicle biogenesis | 6/966 | 22/17913 | 9e-04 | 0.0087 | 6 |
| GO:0097529 | myeloid leukocyte migration | 20/966 | 170/17913 | 9e-04 | 0.0087 | 20 |
| GO:0055067 | monovalent inorganic cation homeostasis | 16/966 | 122/17913 | 9e-04 | 0.0087 | 16 |
| GO:0017014 | protein nitrosylation | 5/966 | 15/17913 | 9e-04 | 0.0087 | 5 |
| GO:0018119 | peptidyl-cysteine S-nitrosylation | 5/966 | 15/17913 | 9e-04 | 0.0087 | 5 |
| GO:0010769 | regulation of cell morphogenesis involved in differentiation | 27/966 | 260/17913 | 9e-04 | 0.0088 | 27 |
| GO:0040017 | positive regulation of locomotion | 49/966 | 570/17913 | 9e-04 | 0.0088 | 49 |
| GO:0000278 | mitotic cell cycle | 73/966 | 934/17913 | 9e-04 | 0.0089 | 73 |
| GO:0031349 | positive regulation of defense response | 45/966 | 512/17913 | 9e-04 | 0.0089 | 45 |
| GO:0051028 | mRNA transport | 18/966 | 146/17913 | 9e-04 | 0.0089 | 18 |
| GO:0016055 | Wnt signaling pathway | 44/966 | 498/17913 | 9e-04 | 0.0091 | 44 |
| GO:0052547 | regulation of peptidase activity | 37/966 | 398/17913 | 9e-04 | 0.0091 | 37 |
| GO:0032760 | positive regulation of tumor necrosis factor production | 12/966 | 78/17913 | 9e-04 | 0.0091 | 12 |
| GO:0050821 | protein stabilization | 20/966 | 171/17913 | 9e-04 | 0.0092 | 20 |
| GO:0000209 | protein polyubiquitination | 29/966 | 288/17913 | 9e-04 | 0.0092 | 29 |
| GO:0032648 | regulation of interferon-beta production | 9/966 | 48/17913 | 9e-04 | 0.0092 | 9 |
| GO:0043392 | negative regulation of DNA binding | 9/966 | 48/17913 | 9e-04 | 0.0092 | 9 |
| GO:0048259 | regulation of receptor-mediated endocytosis | 14/966 | 100/17913 | 9e-04 | 0.0092 | 14 |
| GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 14/966 | 100/17913 | 9e-04 | 0.0092 | 14 |
| GO:0042775 | mitochondrial ATP synthesis coupled electron transport | 13/966 | 89/17913 | 9e-04 | 0.0093 | 13 |
| GO:0035967 | cellular response to topologically incorrect protein | 17/966 | 135/17913 | 1e-03 | 0.0095 | 17 |
| GO:0000187 | activation of MAPK activity | 18/966 | 147/17913 | 1e-03 | 0.0095 | 18 |
| GO:0198738 | cell-cell signaling by wnt | 44/966 | 500/17913 | 1e-03 | 0.0096 | 44 |
| GO:0070371 | ERK1 and ERK2 cascade | 29/966 | 289/17913 | 1e-03 | 0.0096 | 29 |
| GO:0008016 | regulation of heart contraction | 26/966 | 249/17913 | 1e-03 | 0.0097 | 26 |
| GO:0007411 | axon guidance | 23/966 | 210/17913 | 1e-03 | 0.0097 | 23 |
| GO:2001234 | negative regulation of apoptotic signaling pathway | 24/966 | 223/17913 | 1e-03 | 0.0098 | 24 |
| GO:0009167 | purine ribonucleoside monophosphate metabolic process | 31/966 | 317/17913 | 1e-03 | 0.0100 | 31 |
| ID | Description | GeneRatio | BgRatio | pvalue | p.adjust | Count |
|---|---|---|---|---|---|---|
| GO:0006521 | regulation of cellular amino acid metabolic process | 11/170 | 61/17913 | 0e+00 | 0.0000 | 11 |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | 13/170 | 107/17913 | 0e+00 | 0.0000 | 13 |
| GO:0090175 | regulation of establishment of planar polarity | 13/170 | 109/17913 | 0e+00 | 0.0000 | 13 |
| GO:0001736 | establishment of planar polarity | 13/170 | 123/17913 | 0e+00 | 0.0000 | 13 |
| GO:0007164 | establishment of tissue polarity | 13/170 | 123/17913 | 0e+00 | 0.0000 | 13 |
| GO:0033238 | regulation of cellular amine metabolic process | 11/170 | 80/17913 | 0e+00 | 0.0000 | 11 |
| GO:0016579 | protein deubiquitination | 17/170 | 260/17913 | 0e+00 | 0.0000 | 17 |
| GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | 11/170 | 85/17913 | 0e+00 | 0.0000 | 11 |
| GO:0001738 | morphogenesis of a polarized epithelium | 13/170 | 139/17913 | 0e+00 | 0.0000 | 13 |
| GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 10/170 | 69/17913 | 0e+00 | 0.0000 | 10 |
| GO:0043620 | regulation of DNA-templated transcription in response to stress | 12/170 | 115/17913 | 0e+00 | 0.0000 | 12 |
| GO:0070646 | protein modification by small protein removal | 17/170 | 273/17913 | 0e+00 | 0.0000 | 17 |
| GO:0035567 | non-canonical Wnt signaling pathway | 13/170 | 145/17913 | 0e+00 | 0.0000 | 13 |
| GO:1902036 | regulation of hematopoietic stem cell differentiation | 10/170 | 72/17913 | 0e+00 | 0.0000 | 10 |
| GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 11/170 | 95/17913 | 0e+00 | 0.0000 | 11 |
| GO:1902750 | negative regulation of cell cycle G2/M phase transition | 11/170 | 97/17913 | 0e+00 | 0.0000 | 11 |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 10/170 | 75/17913 | 0e+00 | 0.0000 | 10 |
| GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 10/170 | 77/17913 | 0e+00 | 0.0000 | 10 |
| GO:0071347 | cellular response to interleukin-1 | 13/170 | 156/17913 | 0e+00 | 0.0000 | 13 |
| GO:0070498 | interleukin-1-mediated signaling pathway | 11/170 | 101/17913 | 0e+00 | 0.0000 | 11 |
| GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 10/170 | 78/17913 | 0e+00 | 0.0000 | 10 |
| GO:0031145 | anaphase-promoting complex-dependent catabolic process | 10/170 | 81/17913 | 0e+00 | 0.0000 | 10 |
| GO:0043632 | modification-dependent macromolecule catabolic process | 22/170 | 522/17913 | 0e+00 | 0.0000 | 22 |
| GO:0060218 | hematopoietic stem cell differentiation | 10/170 | 83/17913 | 0e+00 | 0.0000 | 10 |
| GO:0043618 | regulation of transcription from RNA polymerase II promoter in response to stress | 11/170 | 109/17913 | 0e+00 | 0.0000 | 11 |
| GO:1901532 | regulation of hematopoietic progenitor cell differentiation | 10/170 | 85/17913 | 0e+00 | 0.0000 | 10 |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 17/170 | 328/17913 | 0e+00 | 0.0000 | 17 |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 21/170 | 510/17913 | 0e+00 | 0.0000 | 21 |
| GO:1905330 | regulation of morphogenesis of an epithelium | 13/170 | 181/17913 | 0e+00 | 0.0000 | 13 |
| GO:0019941 | modification-dependent protein catabolic process | 21/170 | 515/17913 | 0e+00 | 0.0000 | 21 |
| GO:0044106 | cellular amine metabolic process | 11/170 | 121/17913 | 0e+00 | 0.0000 | 11 |
| GO:0070555 | response to interleukin-1 | 13/170 | 183/17913 | 0e+00 | 0.0000 | 13 |
| GO:0009308 | amine metabolic process | 11/170 | 128/17913 | 0e+00 | 0.0000 | 11 |
| GO:1903311 | regulation of mRNA metabolic process | 15/170 | 275/17913 | 0e+00 | 0.0000 | 15 |
| GO:0033209 | tumor necrosis factor-mediated signaling pathway | 12/170 | 167/17913 | 0e+00 | 0.0000 | 12 |
| GO:0002218 | activation of innate immune response | 16/170 | 319/17913 | 0e+00 | 0.0000 | 16 |
| GO:0002478 | antigen processing and presentation of exogenous peptide antigen | 12/170 | 174/17913 | 0e+00 | 0.0000 | 12 |
| GO:0019884 | antigen processing and presentation of exogenous antigen | 12/170 | 176/17913 | 0e+00 | 0.0000 | 12 |
| GO:2000027 | regulation of animal organ morphogenesis | 14/170 | 250/17913 | 0e+00 | 0.0000 | 14 |
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | 10/170 | 113/17913 | 0e+00 | 0.0000 | 10 |
| GO:0010565 | regulation of cellular ketone metabolic process | 12/170 | 178/17913 | 0e+00 | 0.0000 | 12 |
| GO:0010498 | proteasomal protein catabolic process | 17/170 | 382/17913 | 0e+00 | 0.0000 | 17 |
| GO:0002220 | innate immune response activating cell surface receptor signaling pathway | 10/170 | 116/17913 | 0e+00 | 0.0000 | 10 |
| GO:2000736 | regulation of stem cell differentiation | 10/170 | 116/17913 | 0e+00 | 0.0000 | 10 |
| GO:0002758 | innate immune response-activating signal transduction | 15/170 | 298/17913 | 0e+00 | 0.0000 | 15 |
| GO:0019882 | antigen processing and presentation | 13/170 | 220/17913 | 0e+00 | 0.0000 | 13 |
| GO:0051603 | proteolysis involved in cellular protein catabolic process | 21/170 | 590/17913 | 0e+00 | 0.0000 | 21 |
| GO:0010389 | regulation of G2/M transition of mitotic cell cycle | 12/170 | 185/17913 | 0e+00 | 0.0000 | 12 |
| GO:0044257 | cellular protein catabolic process | 22/170 | 648/17913 | 0e+00 | 0.0000 | 22 |
| GO:0048002 | antigen processing and presentation of peptide antigen | 12/170 | 188/17913 | 0e+00 | 0.0000 | 12 |
| GO:0043488 | regulation of mRNA stability | 11/170 | 158/17913 | 0e+00 | 0.0000 | 11 |
| GO:0071453 | cellular response to oxygen levels | 13/170 | 237/17913 | 0e+00 | 0.0000 | 13 |
| GO:0043487 | regulation of RNA stability | 11/170 | 163/17913 | 0e+00 | 0.0000 | 11 |
| GO:1902749 | regulation of cell cycle G2/M phase transition | 12/170 | 202/17913 | 0e+00 | 0.0000 | 12 |
| GO:0042180 | cellular ketone metabolic process | 13/170 | 241/17913 | 0e+00 | 0.0000 | 13 |
| GO:0045089 | positive regulation of innate immune response | 16/170 | 373/17913 | 0e+00 | 0.0000 | 16 |
| GO:0038095 | Fc-epsilon receptor signaling pathway | 11/170 | 169/17913 | 0e+00 | 0.0000 | 11 |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway | 11/170 | 169/17913 | 0e+00 | 0.0000 | 11 |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | 10/170 | 135/17913 | 0e+00 | 0.0000 | 10 |
| GO:0000209 | protein polyubiquitination | 14/170 | 288/17913 | 0e+00 | 0.0000 | 14 |
| GO:0071456 | cellular response to hypoxia | 12/170 | 210/17913 | 0e+00 | 0.0000 | 12 |
| GO:0070482 | response to oxygen levels | 16/170 | 389/17913 | 0e+00 | 0.0000 | 16 |
| GO:0061013 | regulation of mRNA catabolic process | 11/170 | 178/17913 | 0e+00 | 0.0001 | 11 |
| GO:0038061 | NIK/NF-kappaB signaling | 11/170 | 179/17913 | 0e+00 | 0.0001 | 11 |
| GO:0050852 | T cell receptor signaling pathway | 11/170 | 180/17913 | 0e+00 | 0.0001 | 11 |
| GO:0036294 | cellular response to decreased oxygen levels | 12/170 | 220/17913 | 0e+00 | 0.0001 | 12 |
| GO:0001666 | response to hypoxia | 15/170 | 354/17913 | 0e+00 | 0.0001 | 15 |
| GO:0031349 | positive regulation of defense response | 18/170 | 512/17913 | 0e+00 | 0.0001 | 18 |
| GO:0036293 | response to decreased oxygen levels | 15/170 | 365/17913 | 0e+00 | 0.0001 | 15 |
| GO:0002244 | hematopoietic progenitor cell differentiation | 10/170 | 158/17913 | 0e+00 | 0.0001 | 10 |
| GO:0048863 | stem cell differentiation | 12/170 | 237/17913 | 0e+00 | 0.0001 | 12 |
| GO:0000086 | G2/M transition of mitotic cell cycle | 12/170 | 238/17913 | 0e+00 | 0.0001 | 12 |
| GO:0030178 | negative regulation of Wnt signaling pathway | 11/170 | 198/17913 | 0e+00 | 0.0001 | 11 |
| GO:0038093 | Fc receptor signaling pathway | 12/170 | 241/17913 | 0e+00 | 0.0001 | 12 |
| GO:0062012 | regulation of small molecule metabolic process | 16/170 | 439/17913 | 0e+00 | 0.0002 | 16 |
| GO:0045088 | regulation of innate immune response | 16/170 | 440/17913 | 0e+00 | 0.0002 | 16 |
| GO:0030177 | positive regulation of Wnt signaling pathway | 10/170 | 170/17913 | 0e+00 | 0.0002 | 10 |
| GO:0006520 | cellular amino acid metabolic process | 14/170 | 347/17913 | 0e+00 | 0.0002 | 14 |
| GO:0044839 | cell cycle G2/M phase transition | 12/170 | 257/17913 | 0e+00 | 0.0002 | 12 |
| GO:0030163 | protein catabolic process | 22/170 | 799/17913 | 0e+00 | 0.0003 | 22 |
| GO:0071356 | cellular response to tumor necrosis factor | 12/170 | 266/17913 | 0e+00 | 0.0003 | 12 |
| GO:0016071 | mRNA metabolic process | 22/170 | 815/17913 | 0e+00 | 0.0004 | 22 |
| GO:0050851 | antigen receptor-mediated signaling pathway | 11/170 | 224/17913 | 0e+00 | 0.0004 | 11 |
| GO:0006401 | RNA catabolic process | 14/170 | 368/17913 | 0e+00 | 0.0004 | 14 |
| GO:0002253 | activation of immune response | 19/170 | 647/17913 | 0e+00 | 0.0005 | 19 |
| GO:1901991 | negative regulation of mitotic cell cycle phase transition | 11/170 | 235/17913 | 0e+00 | 0.0005 | 11 |
| GO:0030097 | hemopoiesis | 22/170 | 847/17913 | 0e+00 | 0.0006 | 22 |
| GO:0034612 | response to tumor necrosis factor | 12/170 | 284/17913 | 0e+00 | 0.0006 | 12 |
| GO:0016567 | protein ubiquitination | 21/170 | 794/17913 | 0e+00 | 0.0007 | 21 |
| GO:0010948 | negative regulation of cell cycle process | 13/170 | 344/17913 | 0e+00 | 0.0009 | 13 |
| GO:0032446 | protein modification by small protein conjugation | 22/170 | 873/17913 | 0e+00 | 0.0009 | 22 |
| GO:0050778 | positive regulation of immune response | 21/170 | 809/17913 | 0e+00 | 0.0009 | 21 |
| GO:0002757 | immune response-activating signal transduction | 17/170 | 567/17913 | 0e+00 | 0.0009 | 17 |
| GO:1901988 | negative regulation of cell cycle phase transition | 11/170 | 254/17913 | 0e+00 | 0.0010 | 11 |
| GO:0048534 | hematopoietic or lymphoid organ development | 22/170 | 890/17913 | 0e+00 | 0.0012 | 22 |
| GO:1903706 | regulation of hemopoiesis | 15/170 | 468/17913 | 0e+00 | 0.0013 | 15 |
| GO:0060070 | canonical Wnt signaling pathway | 12/170 | 311/17913 | 0e+00 | 0.0013 | 12 |
| GO:0002009 | morphogenesis of an epithelium | 16/170 | 527/17913 | 0e+00 | 0.0013 | 16 |
| GO:0060828 | regulation of canonical Wnt signaling pathway | 11/170 | 264/17913 | 0e+00 | 0.0014 | 11 |
| GO:0002764 | immune response-regulating signaling pathway | 17/170 | 603/17913 | 1e-04 | 0.0019 | 17 |
| GO:0030104 | water homeostasis | 6/170 | 74/17913 | 1e-04 | 0.0022 | 6 |
| GO:0002520 | immune system development | 22/170 | 938/17913 | 1e-04 | 0.0024 | 22 |
| GO:0016055 | Wnt signaling pathway | 15/170 | 498/17913 | 1e-04 | 0.0024 | 15 |
| GO:0198738 | cell-cell signaling by wnt | 15/170 | 500/17913 | 1e-04 | 0.0025 | 15 |
| GO:1901361 | organic cyclic compound catabolic process | 18/170 | 685/17913 | 1e-04 | 0.0027 | 18 |
| GO:0006402 | mRNA catabolic process | 12/170 | 338/17913 | 1e-04 | 0.0027 | 12 |
| GO:0000165 | MAPK cascade | 21/170 | 882/17913 | 1e-04 | 0.0027 | 21 |
| GO:0031347 | regulation of defense response | 21/170 | 885/17913 | 1e-04 | 0.0028 | 21 |
| GO:0023014 | signal transduction by protein phosphorylation | 21/170 | 886/17913 | 1e-04 | 0.0028 | 21 |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 13/170 | 399/17913 | 1e-04 | 0.0032 | 13 |
| GO:0048729 | tissue morphogenesis | 17/170 | 635/17913 | 1e-04 | 0.0032 | 17 |
| GO:0019439 | aromatic compound catabolic process | 17/170 | 655/17913 | 2e-04 | 0.0045 | 17 |
| GO:0043687 | post-translational protein modification | 12/170 | 360/17913 | 2e-04 | 0.0046 | 12 |
| GO:0045930 | negative regulation of mitotic cell cycle | 11/170 | 308/17913 | 2e-04 | 0.0047 | 11 |
| GO:0034655 | nucleobase-containing compound catabolic process | 16/170 | 598/17913 | 2e-04 | 0.0049 | 16 |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 13/170 | 434/17913 | 3e-04 | 0.0067 | 13 |
| GO:0031329 | regulation of cellular catabolic process | 19/170 | 814/17913 | 3e-04 | 0.0068 | 19 |
| GO:0045087 | innate immune response | 20/170 | 893/17913 | 3e-04 | 0.0080 | 20 |
| GO:0019221 | cytokine-mediated signaling pathway | 18/170 | 764/17913 | 4e-04 | 0.0088 | 18 |
| GO:0046700 | heterocycle catabolic process | 16/170 | 641/17913 | 4e-04 | 0.0100 | 16 |